If the crash occurs right after launching the program, and you've got XP SP2 or Vista, then it may be "Data Execution Prevention" (DEP). Turn off DEP in the control panel:
System | properties | advanced | Data Execution Prevention.
If you've got it set for "all programs", then add ClipMate to the exception list.
Note: This should no longer be an issue with ClipMate 7.2 or later.